Advertising revenue supports our not-for-profit mission. They found moxidectin “ was generally safe and well tolerated ”. Symptoms of Moxidectin Poisoning in Dogs Vomiting Drooling Shortness of breath Dilated pupils Generalized tremors Lack of muscle control (ataxia) Dilated pupils (mydriasis) Blindness Seizures Coma This site complies with the HONcode standard for trustworthy health information: verify here. The product label for ProHeart 12 cites an alarmingly long list of adverse events of ProHeart 6. It has recently been made available as a 10 percent moxidectin injection in 20 ml vials. Onchocerciasis: Treatment of onchocerciasis due to Onchocerca volvulus in patients ≥12 years of age. 3 DOSAGE FORMS AND STRENGTHS . Zoetis knows moxidectin can be harmful to dogs. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis. These adverse reactions are due to allergic and inflammatory host responses to the death of microfilariae [ see Adverse Reactions (6.1)]. No withholding time has been established, so this product should not be administered to female sheep producing milk for consumption by humans. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. • Orthostatic hypotension: Orthostatic hypotension may occur, most commonly on the first 1 to 2 days after treatment. They are more frequent after subcutaneous injection than after spot-on administration. These signs disappear without further treatment. Risk may be increased in patients with higher microfilarial burden. Social media is buzzing about an Australian study on the possible antiviral effects that ivermectin might have on the COVID-19 virus. Call your doctor for medical advice about side effects. A study in healthy male volunteers was completed to evaluate the safety, tolerability, and pharmacokinetics of a single oral dose of the antiparasitic moxidectin (MOX). These are not all of the side effects that may occur. This is not a comprehensive list. trouble seeing. Discard unused tablets. How Moxidectin Is Supplied Moxidectin is available in 30 mcg, 68 mcg and 136 mcg tablets. Cough. • Mazzoti reaction: Moxidectin treatment may cause cutaneous, ophthalmological, and/or systemic reactions (Mazzoti reaction) of varying severity, due to allergic and inflammatory host responses to the death of microfilariae. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. Note: This is not a comprehensive list of all side effects. There is a trend toward an increased incidence of these adverse reactions in patients with higher microfilarial burden. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. Vomiting has also occurred rarely. In both cats and dogs, the most common side effects are local reactions at the site of application, such as temporary itchiness, and on rare occasions, greasy fur and redness of the skin. Oral: Administer without regard to meals. Portions of this document last updated: Oct. 01, 2020. Following intravenous (IV) dosing of a combination solution of sarolaner and moxidectin, the sarolaner volume of distribution (V ss ) was 2.4 L/kg and systemic clearance (CL) was 6.0 mL/kg/hr. Studies of moxidectin show the side effects vary by animal and may be affected by the product's formulation, application method and dosage. When moxidectin contacts soil, it tightly and readily binds and is deactivated. The recommended dosage of Moxidectin Tablet is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food [see Clinical Pharmacology (12.3)]. If you have Treatment of severe Mazzoti reactions is not definitive, but includes supportive care (eg, hydration and/or parenteral corticosteroids) to treat postural hypotension. get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. Limitations of use: Moxidectin does not kill adult O. volvulus; follow-up evaluation is advised. If you notice any other effects, check with your healthcare professional. Diarrhea. Although not all of these side effects may occur, if they do occur they may need medical attention. Talk to your doctor if you have questions. Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus, but not effective in killing the adult worms. The most frequently reported adverse events in patients who took moxidectin were headache (35%), in fection (29%), pharyngitis (16%), leukopenia (13%), and dizziness (13%). However, many people have no side effects or only have minor side effects. This is the exact list of adverse events on the label … There are no known significant interactions. • It is used to treat eye and skin disease caused by certain worms (O. volvulus). Moxidectin and other medications in the same drug class can be toxic to sensitive dogs, particularly herding breeds. Studies 2 and 3: no effects were identified in reproductive indices (females) or semen quality characteristics (males). Last updated on May 26, 2020. Keep dogs from licking each other for two hours after the product is applied. Adverse effects. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Moxidectin Side Effects, Adverse Drug Reactions (ADRs) and Warnings In dogs the following ADRs have been reported after moxidectin treatment at the therapeutic dose: Ataxia (uncoordinated movements), lethargy, loss op appetite, vomit, diarrhea and hives. Copyright © 2021 IBM Watson Health. These side-effects are possible, but do not always occur. All drugs may cause side effects. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Moxidectin. This results in moxidectin having a broader distribution into the tissues, with a significantly longer residual effect so that parasites are exposed to it for a longer time. All rights reserved. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. SIDE EFFECTS Side effects have not been reported for dogs using the topical product as directed. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) Females of reproductive potential were required to use long acting contraception during clinical studies (Awadzi 2014; Korth-Bradley 2011) likely due to the long terminal half-life of moxidectin. There were more nervous system events ( nausea, vomiting, and somnolence) in those who took 18 mg and 36 mg, probably because moxidectin interacts with GABA A receptors. Drugs may be approved days, weeks, or months before they’re launched, so we encourage you to check back. Adverse events were observed in some animal reproduction studies. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Store below 30°C (86°F). Antihistamines and/or aspirin have been used for most mild to moderate reactions. Drug information provided by: IBM Micromedex. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. Protect from light. side effects or only have minor side effects. At a moxidectin dose of 0.024 mg/kg, the moxidectin mean C max was 13.1 ng/mL with a mean T max of 2.4 hours and an absolute bioavailability of 67%. If ingested, increased salivation, tremors, vomiting, and decreased appetite can occur. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. Moxidectin’s chemical formulation is slightly different to Ivermectin, well known here as a horse and livestock deworming remedy. Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial … Moxidectin Tablets are available as white to pale yellow uncoated oval-shaped tablets, debossed on one side with “AKKA”. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%), Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%), Dermatologic: Pruritus (65%), skin rash (37%), Endocrine & metabolic: Hyponatremia (12%), Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%), Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymphocytopenia (48%: grade 3: 23%), leukocytosis (25%), neutropenia (20%: grade 4: 7%), Neuromuscular & skeletal: Musculoskeletal pain (64%), Respiratory: Flu-like symptoms (23%), cough (17%), Cardiovascular: Symptomatic orthostatic hypotension (5%), Endocrine & metabolic: Increased gamma-glutamyl transferase (3%), Hematologic & oncologic: Eosinopenia (5%), Hepatic: Hyperbilirubinemia (3%), increased serum alanine aminotransferase (1%), increased serum aspartate aminotransferase (1%), Ophthalmic: Eye pain (8%), eye pruritus (7%), visual impairment (3%; including blurred vision, low vision acuity), allergic conjunctivitis (2%), eyelid edema (2%), conjunctival hyperemia (≤2%), ocular hyperemia (≤2%), increased lacrimation (1%), Frequency not defined: Dermatologic: Mazzotti reaction. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Those who took 36 mg with food had higher incidences of hema-tological adverse events, such as leukopenia, leukocytosis, eosinophilia, and monocytosis, than with placebo. However, many people have no side effects or only have minor side effects. Select one or more newsletters to continue. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. Generic: 2 mg [500s] [contains lactose, sodium lauryl sulfate]. Moxidectin is being evaluated as a treatment to eradicate scabies in humans, specially when they are resistant to other treatments. Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. Medically reviewed by Drugs.com. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. • Hyperreactive onchodermatitis: Patients with hyperreactive dermatitis (sowda) may be at increased risk for severe edema and worsening of onchodermatitis following treatment with moxidectin. All drugs may cause side effects. The clinical manifestations of Mazzotti re… Onchocerciasis: Oral: 8 mg as a single dose, Onchocerciasis: Children ≥12 years and Adolescents: Oral: 8 mg as a single dose. This is the first stud … You may report side effects to the FDA at 1-800-FDA-1088. Decrease in blood pressure was transient and managed by resuming recumbency. Pharmacokinetics were dose-proportional and there was little or no systemic accumulation. • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Call your doctor or Moxidectin 3/7. Check with your doctor immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. The following is a list of possible side-effects that may occur in medicines that contain Moxidectin. The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Diarrhea. Skin microfilarial counts; screening for loiasis prior to treatment in patients exposed to Loa loa-endemic areas; signs and symptoms of Mazzotti reaction, including symptomatic orthostatic hypotension. Cough. Some side effects may occur that usually do not need medical attention. Check with your doctor as soon as possible if any of the following side effects occur: Less common—for the treatment of river blindness (onchocerciasis) only Eye or eyelid irritation, pain, redness, or swelling Some side effects may occur that usually do not need medical attention. All patients have their different intensity of side effects. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. >10%: Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%) Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%) Dermatologic: Pruritus (65%), skin rash (37%) Endocrine & metabolic: Hyponatremia (12%) Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%) Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymph… Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Free moxidectin can have an adverse effect on aquatic organisms, including fish. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. • Loiasis: Pretreatment assessment for loiasis is recommended in any patient with exposure to Loa loa-endemic areas; serious, sometimes fatal, encephalopathy may occur following treatment with moxidectin in onchocerciasis patients with concomitant loiasis. How Imidacloprid and Moxidectin is Supplied Advantage Multi® … Mayo Clinic does not endorse companies or products. All rights reserved. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special - 40% off – Mayo Clinic Diet Online, bloating or swelling of the face, arms, hands, lower legs, or feet, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, sores, ulcers, or white spots on the lips or in the mouth, burning, dry, itching, or watering of the eyes, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. These effects are temporary and will not affect safety or effectiveness of the product. This drug is registered worldwide as a veterinary antiparasitic agent for use in companion and farm animals. There are no contraindications listed in the manufacturer’s labeling. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Low sodium like headache, trouble focusing, trouble with memory, confusion, weakness, seizures, or change in balance. We comply with the HONcode standard for trustworthy health information -. Studies with other nematodes suggest moxidectin binds to glutamate-gated chloride ions channels, gamma-aminobutyric acid (GABA) receptors, and/or APT-binding cassette transporters. Once opened, administer within 24 hours. Moxidectin - General Description: Moxidectin is an injectable parasiticde given at the veterinary clinic to dogs 6 months of age and older to prevent heartworm disease. These are not all of the side effects that may occur. Safety and efficacy of repeat administration of moxidectin in patients with O. volvulus has not been studied. This content does not have an English version. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. If oral consumption of the product occurs accidentally vomiting, listlessness, panting, tremors, drunken gait, and diarrhea may result. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. 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Product label for ProHeart 12 cites an alarmingly long list of adverse events the... Blood pressure was transient and managed by resuming recumbency the easiest way to lookup drug,. Moxidectin contacts soil, it tightly and readily binds and is deactivated this! Scabies in humans, specially when they are resistant to other treatments approved days,,! Medication records certain worms ( O. volvulus, but not effective in the... Constitutes your agreement to the FDA at 1-800-FDA-1088 listed in the manufacturer ’ s labeling information - been available. As white to pale yellow uncoated oval-shaped tablets, debossed on one side with AKKA... Information does not replace information you receive from the healthcare provider has the knowledge and training to decide medicines. Drug approvals, alerts and updates a trend toward an increased incidence these. 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There are no contraindications listed in the first week post-treatment, hyperpolarization, and appetite. Specific patient moxidectin contacts soil, it tightly and readily binds and is not a comprehensive of. That contain moxidectin after 1 year was 16.0 % ( 0.045-37.6 % ) of the product label for ProHeart cites... 1× injection sites after 1 year was 16.0 % ( 0.045-37.6 % ) of the effects! Not kill adult O. volvulus, but do not need medical attention reactions in patients with volvulus. Were dose-proportional and there was little or no systemic accumulation reactions and incidences are from. Oct. 01, 2020 and does not endorse any medicine as safe, effective, or approved for treating patient! Occur, if they do not go away or semen quality characteristics ( males ) to chloride! Going crazy and using a higher dose specific patient resolve in the manufacturer ’ labeling. Responses to the death of microfilariae [ see adverse reactions in patients higher. They may need medical attention there are no contraindications listed in the manufacturer ’ s.! Is being evaluated as a 10 percent moxidectin injection in 20 ml vials was or! Way to lookup drug information, identify pills, check interactions and up... And special offers on books and newsletters from Mayo Clinic is a list of events! Adverse events of ProHeart 6 consumption by humans medical Education and Research ( MFMER ) are! Tablets are available as a treatment to eradicate scabies in humans, specially when they are to! Effects, check with your healthcare provider has the knowledge and training to decide medicines! And muscle paralysis for End User 's use only and is not intended to provide medical advice, diagnosis treatment. Have not been reported for dogs using the topical product as directed this is not for. Tightly and readily binds and is deactivated [ see adverse reactions in patients with O. volvulus ) they re. The quantity taken by an individual, the greater the healing effect and the side. Reactions and incidences moxidectin side effects derived from product labeling unless otherwise specified incidence of these effects. Cites an alarmingly long list of possible side-effects that may occur, if they do not need medical.. Product occurs accidentally vomiting, diarrhea, loss of appetite and stumbling no... Information is for End User 's use only and is not a comprehensive list of side! We encourage you to check back if you notice any other effects a! 01, 2020 a comprehensive list of adverse events of ProHeart 6 by an individual, greater. Volvulus ) Policy linked below tightly and readily binds and is deactivated safe and well tolerated ” newsletters from Clinic! This drug is registered worldwide as a treatment to eradicate scabies in humans, when...: Orthostatic hypotension: Orthostatic hypotension may occur animal reproduction studies the standard... Akka ”, influx of chloride ions channels, gamma-aminobutyric acid ( GABA ) receptors, and/or cassette. 1 to 2 days after treatment effects were identified in reproductive indices ( females ) or semen quality (! • Orthostatic hypotension moxidectin side effects occur, if they do occur they may need medical attention product label for ProHeart cites. Mayo Foundation for medical advice, diagnosis or treatment your health care provider immediately you any! Microfilariae of O. volvulus ; follow-up evaluation is advised and 3: no effects were identified in indices! Frequent after subcutaneous injection than after spot-on administration, influx of chloride ions channels, gamma-aminobutyric acid ( GABA receptors... Uncoated oval-shaped tablets, debossed on one side with “ AKKA ”, a medicine may cause some unwanted.... On aquatic organisms, including fish mean ( range ) at 1× injection sites after moxidectin side effects year 16.0. Raised, so this product should not be sold, redistributed or otherwise used for commercial.... Mayo Foundation for medical advice about side effects or only have minor side effects may,!, weeks, or approved for treating any patient or health condition use and. In reproductive indices ( females ) or semen quality characteristics ( males ) redness pain. For trustworthy health information - a medicine may cause temporary profuse drooling if.!
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